Cyclooxygenase-2 Inhibitor Inhibits the Fracture Healing.
نویسندگان
چکیده
منابع مشابه
Effects of Cyclooxygenase-2 Inhibitors on Fracture Healing
Introduction: Non-steroidal anti-inflammatory drugs (NSAID) are among the most widely prescribed drugs worldwide. However, there have been theoretical concerns about the effect of NSAIDs on bone metabolism and healing. These concerns have resurfaced with the recent discover of the Cyclooxygenase-2 (COX-2) isoform which is involved in inflammation and the development of COX-2 specific drugs. The...
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Objective(s): Noise-induced hearing loss (NIHL) is the major cause of acquired hearing loss. Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, is a non- steroidal anti- inflammatory drug (NSAID) with known antioxidant and antineoplastic activity. Therefore, we monitored the extent of temporary noise- induced threshold shifts (TTS) and cochlear damage caused by high level 4- kHz noise exposure t...
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The aim of this research was to investigate the Cyclooxygenase-2 (COX-2) selective inhibition effect on haloperidol-induced catatonia. In this study, the effect of orally, acutely and Sub-chronically administrations of compound 11b [1-(phenyl)-5-(4-methylsulfonylphenyl)-2-ethylthioimidazole] (2, 4 and 8 mg/kg), a newly selective COX-2 inhibitor, was investigated against the haloperidol-induced ...
متن کاملSelective Cyclooxygenase-2 Inhibitor Compound 11b Improves Haloperidol-Induced Catatonia by Enhancing the Striatum Dopaminergic Neurotransmission
The aim of this research was to investigate the Cyclooxygenase-2 (COX-2) selective inhibition effect on haloperidol-induced catatonia. In this study, the effect of orally, acutely and Sub-chronically administrations of compound 11b [1-(phenyl)-5-(4-methylsulfonylphenyl)-2-ethylthioimidazole] (2, 4 and 8 mg/kg), a newly selective COX-2 inhibitor, was investigated against the haloperidol-induced ...
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A substantial amount of evidence has proposed an important role for Cyclooxygenase-2 (COX-2) enzyme in brain diseases and affiliate disorders. The purpose of this research was studying the effects of COX-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and Parkinson’s disease (PD). In this study, the effect of acute and Sub-chronic oral administration ...
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ژورنال
عنوان ژورنال: Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science
سال: 2002
ISSN: 1345-3475,1347-5355
DOI: 10.2114/jpa.21.235